全脑映射接工人含量增加及其与暴露和运动功能的关联
Humberto Monsivais1, Chien-Lin Yeh2, Alex Edmondson3
1School of Health Sciences, Purdue University, West Lafayette, IN, USA.
NeuroImage
|January 26, 2024
概括
接工人的慢性 (Mn) 暴露会导致大脑积累超出基底,影响运动和认知功能. 全脑MRI显示皮质区域的Mn沉积,与神经风险有关.
科学领域:
- 神经科学是一个神经科学.
- 职业健康 职业健康 职业健康
- 医疗成像医学成像
背景情况:
- (Mn) 是必不可少的,但长期暴露会带来神经风险.
- 暴露于Mn烟雾的接工人可能会导致大脑积累,这可能会影响认知和运动功能.
- 之前的研究主要报告了Mn在基底腺中的积累.
研究的目的:
- 开发和应用全脑MRI方法,以在体内绘制溶接工人沉积的地图.
- 为了研究Mn积累的区域差异,超出基底.
- 将沉积与神经行为和运动性能联系起来.
主要方法:
- 对36名暴露接工人和23名非暴露对照者的横截面研究.
- 高分辨率的3DMRI和R1放松映射用于Mn沉积映射.
- 基于voxel的量化 (VBQ) 和区域分析的统计参数映射.
主要成果:
- 全脑MRI放松计成功地绘制了体内Mn沉积的地图.
- 在皮质区域观察到过多的Mn积累,而不仅仅是基底.
- 沉积与职业暴露 (小脑,额叶皮层) 和运动缺陷 (小脑,海马) 相关联.
结论:
- 职业暴露导致大脑沉积的广泛扩散,包括皮质区域.
- 核磁共振可以在体内检测Mn积累及其沿着白质道的分布.
- 沉积与特定的大脑区域和暴露个体的运动功能受损有关.
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