协价对应结果以及在哪里找到它们
Simon C C Lucas1, J Henry Blackwell1, Sarah H Hewitt2
1Hit Discovery, Discovery Sciences, AstraZeneca R&D, Cambridge, UK.
SLAS discovery : advancing life sciences R & D
|January 26, 2024
概括
用于药物发现的共价命中鉴定可以使用电友先选来实现. 本综述详细介绍了用于药物化学项目识别和选择共价化合物的最先进方法.
科学领域:
- 药用化学 医学化学
- 化学生物学 化学生物学
- 药物发现 药物发现 药物发现
背景情况:
- 共价抑制剂在药物发现中越来越重要.
- 电友第一选活动提供了一个可行的策略,用于识别共价命中.
- 成功实施需要遵守最佳实践.
研究的目的:
- 审查当前的共价命中识别技术的最新状态.
- 概述了从共价库中识别匹配结果的方法.
- 为医药化学项目选择化合物提供指导.
主要方法:
- 电友第一选活动.
- 生物物理和生物化学测定.
- 细胞方法. 细胞方法.
- 用DNA编码的图书馆.
主要成果:
- 使用已建立的选技术,可以定期识别共价命中.
- 系统的方法对于成功的共价命中识别至关重要.
- 选择标准对于将共价化合物推进到药物化学计划中至关重要.
结论:
- 协同撞击识别是现代药物发现中的一个实用方法.
- 使用选方法的组合可以提高成功的识别.
- 谨慎的化合物选择对于成功的共价药物开发至关重要.
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