Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

MetaboMiNR: a redstone MiNRcraft tool for nuclear receptors and metabolism.

Endocrinology·2026
Same author

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.

eLife·2025
Same author

Portal bile acid composition and microbiota along the <i>murine</i> intestinal tract exhibit sex differences in physiology.

Gut microbes·2025
Same author

Constitutive Androstane Receptor induces Ribonucleotide Reductase-M2 expression and maintains hepatocyte ploidy in mice.

bioRxiv : the preprint server for biology·2025
Same author

Surface Plasmon Resonance Based Binding Characterization for Screening RNA-Loaded Lipid Nanoparticles (LNPs): Exploring Species Cross-Reactivity in LNP-Apolipoprotein E Interactions.

Molecular pharmaceutics·2025
Same author

Diet-Induced Obesity Modulates Close-Packing of Triacylglycerols in Lipid Droplets of Adipose Tissue.

Journal of the American Chemical Society·2024
Same journal

Higher-Order Clustering of Receptors Real-Time Projected by Plasmon-ruler on the Single Live Cell.

Nano letters·2026
Same journal

Achieving Fermi-Level Depinning and Ideal Metal Contact in <i>β</i>-Ga<sub>2</sub>O<sub>3</sub> Devices via MXene Integration.

Nano letters·2026
Same journal

AI-Assisted Electron Microscopy in Structure-Performance Analysis of Advanced Catalysts: From Atomic Resolution to Statistical Significance.

Nano letters·2026
Same journal

Electrically Switchable Ultraslow Dispersionless Polaritons via Twist Engineering in van der Waals Heterostructures.

Nano letters·2026
Same journal

Correction to "Ultrasonication-Triggered Ubiquitous Assembly of Magnetic Janus Amphiphilic Nanoparticles in Cancer Theranostic Applications".

Nano letters·2026
Same journal

Tunable Proximity Valley Splitting Via Interfacial Exchange Pinning in WSe<sub>2</sub>-CrBr<sub>3</sub>-CrPS<sub>4</sub> Heterostructures.

Nano letters·2026
查看所有相关文章

相关实验视频

Updated: Jun 26, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.1K

装有陈二醇酸的纳米颗粒足以通过诱导线粒体功能来减少脂肪细胞大小.

Weinan Zhou1, Benjamin Lew2, Hyungsoo Choi2

  • 1Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.

Nano letters
|January 26, 2024
PubMed
概括
此摘要是机器生成的。

陈氧胆酸 (CDCA) 纳米颗粒通过降低脂肪细胞大小和增强线粒体功能来减少脑下脂肪. 这为非侵入性脂肪减肥提供了脱氧胆酸 (NaDCA) 的潜在替代品.

关键词:
脂肪组织的脂肪组织.胆酸是什么意思 胆酸是什么意思本地化和持续的交付.线粒体功能 线粒体功能纳米颗粒是如何形成的

更多相关视频

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.0K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.1K

相关实验视频

Last Updated: Jun 26, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.1K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.0K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.1K

科学领域:

  • 生物化学 生物化学
  • 细胞生物学 细胞生物学
  • 纳米技术 纳米技术

背景情况:

  • 过多的脂肪积累会影响健康和福祉.
  • 胆酸是FDA批准的用于下层脂肪的减肥.
  • 合成的脱氧胆酸 (NaDCA) 有炎症和亡等副作用.

研究的目的:

  • 调查切诺二氧化醇酸 (CDCA) 对于下部脂肪的减少.
  • 与NaDCA相比,评估CDCA的疗效和安全性.
  • 探索CDCA在减少脂肪细胞大小方面的机制.

主要方法:

  • 开发了CDCA装载的纳米粒子,用于持续的输送.
  • 纳米颗粒被注射到皮下脂肪库中.
  • 监测脂肪细胞大小和线粒体呼吸.

主要成果:

  • CDCA没有引起脂肪细胞溶解 (细胞分解).
  • CDCA纳米颗粒减少了脂肪细胞的大小.
  • 促进脂肪燃烧和增加线粒体呼吸.

结论:

  • CDCA纳米颗粒为下体脂肪减肥提供了一个更安全的替代方案.
  • 通过增强的线粒体活性,CDCA促进脂肪减少,而不是细胞溶解.
  • 突出了CDCA在非侵入性化品治疗中的潜力.