最低的耐受性血压:一个个性化的目标对所有人?
Paolo Verdecchia1, Fabio Angeli2, Gianpaolo Reboldi3
1Fondazione Umbra Cuore e Ipertensione-ONLUS, Perugia, Italy; Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy.
European journal of internal medicine
|January 26, 2024
概括
确定高血压管理的最佳血压 (BP) 目标是复杂的. 个性化,耐受良好的BP目标平衡了有效性和安全性,因为对固定的目标的证据有限.
科学领域:
- 心脏病学 心脏病学
- 高血压管理 高血压管理
- 临床证据综合研究
背景情况:
- 在高血压中预防心血管并发症的最佳血压 (BP) 目标缺乏明确的证据.
- 目前的指导方针根据患者的因素提供了不同的BP目标,但支持数据往往很弱.
研究的目的:
- 审查在高血压患者中选择血压目标的证据基础.
- 讨论定义最佳BP目标时的挑战和考虑因素.
主要方法:
- 随机策略试验分析,比较密集与不那么密集的BP目标.
- 评估支持不同血压值的证据及其临床影响.
主要成果:
- 更密集的血压治疗目标通常会降低主要心血管事件的风险.
- 强化目标与降低血压和功能障碍等不良影响的增加有关.
结论:
- 由于数据异质性,固定的BP目标缺乏可靠的证据.
- 个性化BP目标,优先考虑最低的耐受性水平,提供最佳的疗效安全权衡.
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