具有极高水溶性的 рибофлавин晶体
Polina V Krikunova1, Eteri R Tolordava2, Natalya A Arkharova1
1FSRC "Crystallography and Photonics" RAS, Moscow 119333, Russia.
ACS applied materials & interfaces
|January 26, 2024
概括
研究人员开发出一种新的,高度水溶性晶体形式的 рибофлавин (维生素B2). 这一突破增强了其作为抗炎和抗菌剂的潜力,改善了治疗应用.
科学领域:
- 生物化学和制药科学 生物化学和制药科学
- 材料科学 是一种材料科学.
背景情况:
- рибофлавин (Rf),或维生素B2,表现出超出补充的潜在治疗性质,包括抗炎,免疫调节,抗氧化,抗癌和抗病毒活动.
- рибофлавин (0.1-0.3 g/L) 的水溶性较差限制了其临床应用,阻碍了与其更容易溶解的代谢物,黄单核酸 (FMN) 和黄氨酸二核酸 (FAD) 的比较.
研究的目的:
- 开发一种方法来显著提高 рибофлавин 的水溶性.
- 为了研究新形式的 рибофлавин的物理化学性质和治疗潜力.
主要方法:
- 将A型 рибофлавин晶体重新结晶成一种新的水友性形式,称为P型.
- 通过从稀释的性溶液中进行再结晶来改变Rf晶体结构.
- 对类型P рибофлавин的物理化学特性进行了全面的分析.
主要成果:
- 实现了前所未有的 рибофлавин 水溶性,达到23.5 g/L.
- 与A型和B型/C型相比,P型 рибофлавин对*黄金葡萄球菌*,*假发菌*,*大肠杆菌*和*沙门氏菌*的临床分离物具有增强的光动力学治疗活性.
- 开发的方法是简单的,廉价的,并产生一种高度溶解的 рибофлавин形式.
结论:
- 一种新型的,高度水溶性晶体形式的 рибофлавин (P型) 已成功合成.
- 预计这一进步将增加利博弗拉的生物活性,并扩大其治疗应用,特别是在光动力学疗法中.
- 这些发现提供了一种具有成本效益的方法来提高维生素B2的治疗效用.
相关概念视频
02:55Solubility of Ionic Compounds
63.2K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
63.2K
01:16Solubility Equilibria: Ionic Product of Water
1.0K
Pure water is a weak electrolyte; only a small amount ionizes into hydrogen and hydroxide ions. At any given temperature, the concentration of undissociated water is almost constant, so the ionic product of water is the product of the hydrogen and hydroxide ion concentrations, denoted as Kw. The square root of Kw gives the individual ion concentrations.
The ionic product of water varies with temperature, and its value is 1.0 x 10−14 at standard experimental conditions. Per Le...
The ionic product of water varies with temperature, and its value is 1.0 x 10−14 at standard experimental conditions. Per Le...
1.0K
04:01Factors Affecting Solubility
33.5K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
33.5K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
309
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
309
01:10Recrystallization: Solid–Solution Equilibria
1.1K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
1.1K
02:19Physical Properties Affecting Solubility
22.7K
Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...
22.7K