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围产阶段给予益生菌对新生小鼠免疫细胞组成的影响

Jessica Rühle¹, Julian Schwarz¹, Stefanie Dietz^1,2

¹Department of Neonatology, Tuebingen University Children's Hospital, Tuebingen, Germany.

Pediatric research

|January 26, 2024

概括

在新生小鼠中,围产期的益生菌暴露显著改变了免疫细胞组成,影响了肠道,肝脏和肺部. 这项研究增强了对益生菌如何影响新生儿发育中的免疫系统的理解.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
发展生物学发展生物学

背景情况:

新生儿和早产婴儿对感染非常敏感.
肠道菌群病原体可以在新生儿的疾病发作之前出现.
益生菌在新生儿重症监护室 (NICU) 中用于预防感染,但其机制尚不清楚.

研究的目的:

为了研究围产期益生菌暴露对新生小鼠免疫细胞组成的影响.
了解益生菌与发育中的免疫系统的相互作用.

主要方法:

怀孕的小鼠从怀孕中期开始接受口服益生菌 (Lactobacillus acidophilus和Bifidobacterium bifidum),直到收获后代.
在后代器官的免疫细胞组成使用流细胞计进行了分析.

主要成果:

益生菌暴露改变了断奶时新生小鼠肠道,肝脏和肺部的免疫细胞组成.
在接受益生菌治疗的小鼠中观察到骨髓状细胞和B细胞的减少,并诱导T细胞.
益生菌暴露影响了胸腺中T细胞的发育.

结论:

围产期益生菌的使用对新生小鼠的免疫细胞组成产生了深刻的影响.
益生菌调节T细胞发育和免疫细胞在关键器官中的分布.
这些发现有助于理解新生儿免疫发育中的益生菌机制.

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