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Updated: Jul 4, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

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甲基脱氧糖化物-多胺组合对抗关键优先级的抗卡巴胺耐药格拉姆阴性细菌

Ana M de Matos1, Patrícia Calado2, Mónica Miranda2

  • 1Centro de Química Estrutural, Institute of Molecular Sciences, Departmento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, 1749-016, Campo Grande, Lisbon, Portugal. amamatos@fc.ul.pt.

Scientific reports
|January 26, 2024
PubMed
概括

新的基于碳水化合物的化合物显示出对抗耐药性格拉姆阴性细菌的承诺,如耐卡巴尼姆耐药的Acinetobacter baumannii (CRAB),Pseudomonas aeruginosa (CRPA) 和Enterobacteriaceae (CRE). 结合胆固醇素,这些新型糖化物有效地向具有挑战性的感染.

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Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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