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Updated: Jul 4, 2025

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
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测量母乳中的母乳度及其在母乳养婴儿中的使用 婴儿暴露预测

Cindy H T Yeung1, Julie Autmizguine2,3, Pooja Dalvi1

  • 1Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada.

Clinical pharmacokinetics
|January 26, 2024
PubMed
概括

使用ezetimibe的哺乳期母亲可以母乳养,因为母乳中的药物水平对婴儿来说不是治疗性的. 这项研究测量了乳中的ezetimibe及其代谢物,通过PBPK建模预测婴儿暴露的最小程度.

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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
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Drug excretion involves various organs, including the liver, intestines, skin, and eyes. In the case of drugs or toxins, they can be actively secreted into bile by transporters in the hepatocyte's canalicular membrane. These substances enter the GI tract during digestion and may be reabsorbed into the body from the intestine. This process, known as enterohepatic recycling, can significantly prolong the presence and effects of a substance in the body. To interrupt this cycle, specific...
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