关于阿萨姆茶提取物富含catechins的最新见解,用于照相衰老和衰老衰老
Mayuree Kanlayavattanakul1,2, Mattaka Khongkow3, Wannita Klinngam3
1School of Cosmetic Science, Mae Fah Luang University, Chiang Rai, 57100, Thailand. mayuree@mfu.ac.th.
Scientific reports
|January 26, 2024
概括
阿萨姆茶提取物 (ATE) 富含儿茶素,有效地对抗紫外线诱导的光衰老和老化的皮肤衰老. 这项研究强调了ATE.
科学领域:
- 皮肤病学和化品
- 植物性疗法 植物性疗法
- 衰老的生物化学 衰老的生物化学
背景情况:
- 茶 (Camellia spp.) 是一种茶. 被认为具有药用特性,与阿萨姆茶 (C. sinensis var. 亚萨米卡 (assamica) 以其苦味特征和潜在的儿茶素含量而闻名.
- 虽然C. sinensis var. 在C. sinensis var. 在C. 亚萨姆茶的苦味表明,阿萨姆茶是一种丰富的生物活性化合物的来源,用于抗衰老应用.
- 关于茶叶对紫外线诱导的光衰老和细胞衰老的疗效的数据仍然有限.
研究的目的:
- 调查阿萨姆茶提取物 (ATE) 的抗衰老潜力,重点关注其对抗紫外线诱导的光衰老和老化的皮肤衰老的影响.
- 为了描述ATE,量化其初级儿茶素 (EGCG),并评估其抗氧化和细胞抗氧化活性.
- 评估ATE对皮肤细胞和人类皮肤模型对抗衰老因素的保护作用.
主要方法:
- 准备和标准化阿萨姆茶提取物 (ATE) 的总含量 (TPC),总黄含量 (TFC) 和总含量 (TTC).
- 高性能液体染色学 (HPLC) 用于表甲基酸盐 (EGCG) 的量化;体外抗氧化剂测定 (ABTS,DPPH,FRAP).
- 在人体皮肤纤维细胞 (HDF) 中进行了体外细胞抗氧化剂测试,在HaCaT/HDF共同培养中进行了光衰老保护测试,在人体皮肤模型中进行了老化衰老测试.
主要成果:
- 与酸相比,ATE在HDF中表现出显著的体外抗氧化能力和卓越的细胞抗氧化活性.
- 通过抑制炎症标记物 (IL-6,IL-8) 和矩阵降解酶 (MMP-1,MMP-9),ATE有效地保护了抗UV诱导的光衰老.
- 在ex vivo皮肤模型中,ATE促进了原蛋白和氨酸的合成,同时抑制了IL-6和MMP-1,这表明它对衰老的疗效. ATE在化学上保持了6个月的稳定性.
结论:
- 阿萨姆茶提取物 (ATE) 富含像EGCG这样的儿茶素,是预防和治疗光衰老和老化的皮肤衰老的有力剂.
- ATE具有显著的抗氧化和细胞保护性质,使其成为下一代抗衰老局部产品的有希望的候选人.
- 这些发现支持ATE的应用,作为一种创新的抗衰老成分,在各种皮肤衰老模型中已证明有效性.
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