长期COVID在儿科-流行病学,诊断和管理中的作用
Nicole Toepfner1, Folke Brinkmann2, Silvia Augustin3
1Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Nicole.Toepfner@ukdd.de.
European journal of pediatrics
|January 26, 2024
概括
COVID-19 (PASC) 或长期COVID的急性后续影响儿童和青少年,导致活动限制. 管理需要个性化,跨学科的方法来解决不同的症状和需求.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- COVID-19 (PASC) 后急性后续,也称为长期COVID,在儿童和青少年感染后四周后呈现了一系列不特定症状.
- 这些症状可以显著影响日常活动和生活质量,即使是在轻度急性COVID-19感染后.
研究的目的:
- 审查当前关于PASC和COVID-19后病情 (PCC) 的知识.
- 综合有关诊断,临床表现和儿科PASC/PCC的管理策略的信息.
主要方法:
- 进行了全面的文献审查,综合了临床研究,专家意见和既定指南的数据.
- 收集了关于儿童和青少年PASC症状表现,诊断挑战和治疗干预措施的信息.
主要成果:
- 儿科PASC/PCC通常在轻度COVID-19后表现出来,常见的症状包括疲劳和劳动不耐受,并可能导致像姿势性心动减速综合征 (PoTS) 或ME/CFS这样的疾病.
- 虽然许多病例在几个月内消失,但症状可能持续超过一年,导致严重的残疾; 目前尚无诊断标志物和因果治疗方法.
- 世界卫生组织 (WHO) 在2023年2月制定了儿童和青少年PCC病例定义,强调症状持续时间和对日常活动的影响.
结论:
- 儿科患者中PASC的特点是异质的严重程度和持续时间,需要逐步,跨学科和个性化的临床管理方法.
- 适应当前的医疗保健结构和扩大研究对于满足受PASC/PCC影响的年轻人的医疗和心理社会需求至关重要.
- 跨学科的合作对于开发协调,多模式的方法来诊断和管理PASC/PCC在世界各地的儿童和青少年至关重要.
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