在转录组范围的关联研究中调整遗传混因素可以改善复杂特征的风险基因的发现

Siming Zhao1,2,3, Wesley Crouse4, Sheng Qian4

  • 1Department of Biomedical Data Science, Dartmouth College, Hanover, NH, USA. siming.zhao@dartmouth.edu.

Nature genetics
|January 26, 2024
PubMed
概括

新的因果TWAS (cTWAS) 方法通过计算表达定量特征位置 (eQTL) 数据中的遗传混因素来改善基因发现,减少全基因组关联研究中的错误阳性.

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