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相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Combinatorial Gene Control02:33

Combinatorial Gene Control

8.3K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.3K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

6.1K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.1K
Synteny and Evolution02:31

Synteny and Evolution

3.3K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.3K
Phylogenetic Trees03:21

Phylogenetic Trees

45.3K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
45.3K
Phylogeny01:23

Phylogeny

44.1K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
44.1K

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相关实验视频

Updated: Jul 4, 2025

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

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在 pangenome 图形上的同线性链接.

Jyotshna Rajput1, Ghanshyam Chandra1, Chirag Jain2

  • 1Department of Computational and Data Sciences, Indian Institute of Science, Bangalore, 560012, Karnataka, India.

Algorithms for molecular biology : AMB
|January 26, 2024
PubMed
概括

这项研究引入了第一个用于循环泛基因组图的共同线性链接的精确算法,提高了复杂基因组的序列对齐精度. 这种新方法增强了基因组多样性表示和分析.

科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 泛基因组参考图提供了对物种遗传多样性的紧表示,超越了线性参考.
  • 有效地将序列对齐到复杂的循环泛基因组图仍然是一个重要的计算挑战.
  • 现有的同线性链接算法对非循环图有效,但对循环有困难.

研究的目的:

  • 开发了第一个实际的表述和准确的算法,用于循环基因组图的同线性链接.
  • 解决当前对齐技术在处理基因组循环中的局限性.
  • 为了提高复杂的泛基因组结构中序列对齐的准确性.

主要方法:

  • 开发了一种新的准确算法,用于共同线性链接,专门设计用于循环基因组图.
  • 为算法的正确性和计算复杂性提供了严格的证明.
  • 通过将模拟的人类长度读数与来自95个人类组合的循环基因组图对齐来评估性能.

主要成果:

  • 拟议的算法提供了一个精确的解决方案,用于循环泛基因组图的共线链.
  • 与现有的启发式方法相比,在序列对齐方面取得了显著的准确性改进.
  • 经验评估证实了该算法的有效性在人类基因组图上.
关键词:
基因组测序是指基因组的测序.路径覆盖 路径覆盖序列对齐方式 序列对齐方式变化图的变化图表

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Associated Chromosome Trap for Identifying Long-range DNA Interactions
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

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结论:

  • 新的算法提供了一个基本的方法,用于在周期性泛基基因组图中准确的序列对齐.
  • 这一进步使得物种内遗传多样性的分析更加精确.
  • 实施方案是公开可用的,用于进一步的研究和应用.