瘤微环境中的巨细胞屏障和潜在的临床应用
Shuai Ji1, Yuqing Shi2, Bo Yin3
1Department of Urinary Surgery, The Shengjing Hospital of China Medical University, Shenyang, 110022, China.
Cell communication and signaling : CCS
|January 26, 2024
概括
瘤相关巨细胞 (TAMs) 在瘤微环境 (TME) 中表现出空间多样性,影响瘤生长和扩散. 了解TAM相互作用是开发新型癌症免疫疗法的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 瘤微环境 (TME) 是一个复杂的生态系统,涉及免疫细胞和结构部件.
- 与瘤相关的巨细胞 (TAMs) 在TME中显示出显著的空间异质性.
- 这种异质性影响瘤的进展,免疫反应,血管新生和转移.
相关概念视频
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:27Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526