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Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
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酸通过调节肠道屏障来促进免疫功能.

Pengcheng Hu1, Meng Yuan1, Bolun Guo2

  • 1Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

International journal of molecular sciences
|January 27, 2024
PubMed
概括

酸通过改善肠道结构和有益细菌来增强肠道健康. 它还加强了肠道屏障,并与流感病毒感染作斗争,为抗生素提供了潜在的替代品.

关键词:
H9N2型流感病毒是H9N2型流感病毒.酸是一种酸.肠道微生物 肠道微生物肠道屏障 肠道屏障 肠道屏障代谢生物组的代谢生物组

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科学领域:

  • 胃肠病学 胃肠病学
  • 微生物学 微生物学
  • 病毒学 病毒学

背景情况:

  • 越来越多的抗生素耐药性需要替代治疗剂.
  • 酸是一种有机化合物,具有多种应用.
  • 了解其在肠道健康和免疫力中的作用至关重要.

研究的目的:

  • 为了研究酸对小鼠肠道紧密结节的作用.
  • 评估酸对肠道微生物群和宿主免疫力的影响.
  • 评估酸对肠道中的禽流感病毒的疗效.

主要方法:

  • 在小鼠中使用酸.
  • 分析肠道形态和小毛病密室比率.
  • 微生物群分析和基因表达分析 (奥克卢丁,ZO-1,克劳丁-1).
  • 肠上皮细胞 (IEC-6) 感染H9N2禽流感病毒.

主要成果:

  • 酸促进了肠道上皮细胞的生长,并增强了状细胞和密室的比率.
  • 观察到有益细菌 (Bifidobacterium, Lactobacillus) 的种群增加.
  • 发现了紧结蛋白 (occludin,ZO-1,claudin-1) 的升调.
  • 酸减少了病毒基因表达,炎症和H9N2流感病毒复制.

结论:

  • 酸强化了肠道紧密结合屏障.
  • 它抑制了肠道流感病毒的复制,并增强了免疫功能.
  • 酸为肠道健康和病毒感染提供了一个有前途的替代药物.