人类的先天性高胰岛素症和小鼠的胰岛素分泌功能障碍是由双基DNAJC3变体引起的

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Alena Welters1,2, Oliver Nortmann1,2, Laura Wörmeyer1,2

  • 1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.

International journal of molecular sciences
|January 27, 2024
PubMed
概括

DNAJC3 缺乏导致高胰岛素性低血糖症 (HH),这是一种身体释放过多胰岛素的情况. 这项研究将DNAJC3变异与HH联系起来,这表明了一种涉及胰腺细胞中调节的新机制.

关键词:
作为BiP/GRP78的共同主持人.泄漏是因为泄漏.细胞内膜网膜的压力应激超胰岛素高血糖低血糖症细胞内平衡的细胞内平衡.单一的糖尿病 单一的糖尿病

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