在炎症性肠道疾病中,饮食脂质控制的肠道炎症和再生间位化过程
Soon Jae Kwon1, Muhammad Sohaib Khan1, Sang Geon Kim1
1Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang-si 10326, Gyeonggi-do, Republic of Korea.
International journal of molecular sciences
|January 27, 2024
概括
饮食中的脂质通过改变免疫反应和肠道健康来影响炎症性肠病 (IBD). 本综述探讨了高脂肪饮食与IBD之间的病理联系,并检查了当前的治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,涉及由免疫系统失调驱动的慢性肠道炎症.
- 关键的炎症性细胞因子,如联素-6和联素-17,强化免疫反应,导致IBD的组织损伤.
- 肥胖和过量摄入卡路里会通过脂毒性和改变脂质供应加剧免疫系统的炎症.
研究的目的:
- 阐明连接饮食脂质摄入与IBD发病和进展的病理基础.
- 审查IBD动物模型中关于高脂肪饮食影响的相互矛盾的发现.
- 讨论与食脂质相关的IBD目前的药理干预措施.
主要方法:
- 对有关食脂质在IBD病变发生中的作用的现有文献的综述.
- 分析高脂肪饮食对免疫细胞功能和肠道完整性的影响.
- 检查脂质,胆汁酸,细胞因子和IBD中的胰岛素抵抗之间的相互作用.
主要成果:
- 高脂肪饮食可以改变肝功能,并通过炎症性细胞因子,氧化应激和肠道微生物群变化促进IBD进展.
- 过多的食脂肪和改变的胆酸与IBD发病和进展有关.
- 干扰肠道上皮细胞中的脂肪酸合成会影响干细胞功能和组织再生,突出显示复杂的脂质-饮食相互作用.
结论:
- 饮食中的脂质在IBD病变发生过程中起着重要作用,影响炎症,免疫反应和肠道修复机制.
- 了解食脂肪,胆酸和肠道环境之间的复杂关系对于管理IBD至关重要.
- 针对脂代谢途径的药理学策略的进一步研究是IBD治疗的必要条件.
关键词:
IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD国际电力委员会 (IECs) 是一个国际电力委员会.这是一种炎症炎症炎症炎症.脂肪摄入量 脂肪摄入量干细胞是干细胞的组成部分.更多相关视频
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