系统性抗生素在急性不可逆转的血栓炎中的使用:评估临床实践和分子见解
Shahnawaz Khijmatgar1, Gionata Bellucci1, Luca Creminelli1
1Complex Structure of Surgical Maxillofacial and Odontostomatology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
International journal of molecular sciences
|January 27, 2024
概括
这次审查发现,尽管有指导方针,但牙医经常为急性不可逆转的胸膜炎开处方全身抗生素. 分子研究提供了新的见解,但临床实践仍然显示全球抗生素处方率很高.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 急性不可逆转的牙炎是一种常见的牙科疾病,需要有效的治疗.
- 系统性抗生素用于肺炎是普遍存在的,但往往缺乏强有力的基于证据的理由.
- 最近的分子研究提供了关于皮病的新见解,以及潜在的治疗点.
研究的目的:
- 系统地审查系统性抗生素在治疗急性不可逆性脉炎的使用情况.
- 将当前的临床实践模式与最近的分子研究成果相结合.
- 弥合临床实践和分子研究之间的差距,以建立基于证据的治疗方法.
主要方法:
- 对2010年以后发表的英语文章进行了电子数据库的系统范围审查.
- 搜索包括原始研究,系统审查,元分析,临床试验和观察性研究.
- 分析的重点是抗生素处方趋势和 púlpitis研究中的分子进步.
主要成果:
- 选择了53篇文章,主要是横截面研究 (76.79%),证据水平低 (VI级).
- 对于急性不可逆转的胸膜炎,一般牙医的平均抗生素处方率为23.89%,专科医生为22.41%,本科生为17.52%.
- 尽管有可用的指导方针,但全球范围内抗生素处方率仍然很高.
结论:
- 在全球范围内,急性不可逆转性脉炎的全身抗生素处方仍然很高,通常不符合基于证据的指导方针.
- 分子研究的进步为我们提供了更深入的了解,并提出了替代治疗策略.
- 进一步将分子洞察力纳入临床实践是必要的,以优化急性不可逆转脉炎的管理,并减少不必要的抗生素使用.
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