维生素D水平低会增加女性患乳腺癌的风险,伊拉克苏莱曼尼亚:一项病例对照研究
Mardin Othman Abdulqadir1, Niaz Mustafa Kamal2, Heshu Sulaiman Rahman3
1Department of Medical Laboratory Technology, College of Health and Medical Technology, 0046 Sulaimani Polytechnic University, Sulaimaniyah, Iraq. mardin.othman@spu.edu.iq.
Cellular and molecular biology (Noisy-le-Grand, France)
|January 27, 2024
概括
维生素D不足与女性患乳腺癌 (BC) 的风险更高有关. 低血清维生素D水平 (<20 ng/L) 显著增加患BC的可能性,即使在调整年龄和BMI后.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 维生素D (Vit D) 在平衡和细胞过程中起着至关重要的作用.
- 现有研究表明,维生素D水平与乳腺癌 (BC) 的发展和预防之间存在联系.
- 了解这种联系对于公共卫生战略和潜在干预措施至关重要.
研究的目的:
- 调查维生素D不足与乳腺癌 (BC) 的发展之间的联系.
- 在特定人群中量化与低血清维生素D度相关的BC风险.
主要方法:
- 一项涉及130名女性 (65名BC患者,65名对照) 的病例控制研究,年龄在伊拉克苏莱曼尼亚市20至60岁.
- 经过超声波,乳房影像和核心活检证实了BC的诊断.
- 使用ELISA测量血清维生素D水平,结果以ng/ml表示.
主要成果:
- 66.1%的BC患者和43.1%的对照人群表现出维生素D水平低于20 ng/L.
- 与对照组 (20.2±8.7 ng/ml) 相比,BC患者的血清维生素D平均水平较低 (17.8±8.6 ng/ml).
- 低维生素D (<20 ng/L) 显著增加BC风险 (OR 2.59),这种关联在调整年龄和BMI (AOR 2.30-3.67) 后仍然存在.
结论:
- 维生素D不足是伊拉克苏莱曼尼亚妇女患乳腺癌的重要危险因素.
- 维持足够的维生素D水平可能在预防乳腺癌方面发挥作用.
- 需要进一步的研究来探索这种关联的机制和临床影响.
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