长期的 metionin 限制:对肠道微生物群和代谢特征的影响
Akash Nagarajan1, Alexander Tate Lasher1, Casey D Morrow2
1Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Aging cell
|January 27, 2024
概括
限制 metionin (MR) 的饮食影响小鼠生理学,但对肠道微生物组合的长期影响很小. 老龄化显著改变肠道细菌比MR饮食更多,短期的饮食变化比长期更明显.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 众所周知,氨酸限制 (MR) 可以延长模型生物的寿命和延迟衰老.
- MR 饮食对肠道微生物群的长期影响仍然基本上未被描述.
- 了解这些影响对于潜在的人类健康应用至关重要.
研究的目的:
- 为了研究甲胺限制 (MR) 饮食对老年雄性小鼠肠道微生物组合的长期影响.
- 为了比较饮食与衰老对微生物多样性和特定种群的影响.
- 评估短期或长期的MR饮食养是否引起更显著的微生物组变化.
主要方法:
- 从6个月到22个月的年龄,雄性小鼠被食MR饮食或控制饮食.
- 监测了包括体重,身体组成和胰岛素敏感性在内的生理参数.
- 用多个时间点 (16S rRNA amplicon测序) 分析了便样本 (1, 18 和 57 周),以评估肠道微生物组合.
主要成果:
- MR饮食导致体重,脂肪质量和骨矿物质密度降低,肌肉质量增加和胰岛素敏感性增加.
- 肠道微生物群多样性 (α和β) 显示了与衰老 (时间点) 相关的变化,但不是MR饮食本身.
- 细菌种群的变化主要与年龄而不是饮食有关,长期MR的变化比短期MR的变化少.
结论:
- 虽然MR饮食在老年小鼠中提供了生理上的好处,但与衰老的影响相比,其对肠道微生物组组成的长期影响是最小的.
- 衰老本身会导致肠道微生物组的显著变化,独立于氨酸的限制.
- 短期的MR饮食干预可能会诱导短暂的微生物变化,但随着长时间的饮食坚持,这些影响会减弱.
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