转录因子,非编码RNA,表观转录组学和表观遗传学在后缺血性神经炎症中的作用
Suresh L Mehta1, Vijay Arruri1, Raghu Vemuganti1,2
1Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin, USA.
Journal of neurochemistry
|January 27, 2024
概括
在中风后持续的神经炎症会使脑损伤恶化,并阻碍恢复. 了解基因调节和RNA修饰等分子机制是开发新中风疗法的关键.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 神经炎症在大脑对中风的反应中起着至关重要的作用.
- 虽然急性炎症有助于修复,但慢性炎症会加剧缺血损伤并损害功能恢复.
- 免疫细胞被招募到缺血大脑中,释放炎症介质,影响细胞反应.
研究的目的:
- 审查中风后神经炎症的复杂分子机制.
- 突出转录因子,非编码RNA和表观遗传修饰在中风结果中的作用.
- 确定潜在的治疗目标,以减轻中风引起的脑损伤和改善恢复.
主要方法:
- 关于中风后神经炎症的现有文献的综述.
- 对参与免疫细胞激活和炎症反应的分子通路的分析.
- 检查基因表达,RNA调节和中风后的表观遗传变化.
主要成果:
- 脑卒中会触发特定分子的释放,这些分子会激活免疫细胞.
- 激活的免疫细胞释放炎症媒介,通过转录因子影响基因表达.
- 非编码RNA和表体转录组修饰动态调节炎症和细胞过程.
- 表观遗传变化,包括DNA甲基化和基因组修饰,对于引发中风的基因反应至关重要.
结论:
- 分子事件的复杂相互作用,包括转录因子激活,ncRNA调节和表观遗传修饰,控制了中风后的炎症.
- 解读这些复杂的神经炎症机制对于开发有效的治疗策略至关重要.
- 针对这些途径有望缓解中风后的功能障碍并增强大脑修复.
更多相关视频
相关概念视频
Chromatin Structure Regulates pre-mRNA Processing
7.0K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
The chromatin structure, especially...
7.0K
Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
General Transcription Factors
5.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.3K
Types of RNA
5.8K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.8K
Regulation of Expression Occurs at Multiple Steps
22.7K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
22.7K


