长度变化在光学连贯性断层扫描血管学特征在正常张力玻璃眼有或没有高近视的特征
Chin Lai1, Lan-Hsin Chuang2,3, Chi-Chun Lai2,3
1School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Acta ophthalmologica
|January 27, 2024
概括
正常张力玻璃眼 (NTG) 眼睛即使有稳定的视野 (VF),也会显示结构性损失. 微血管变化与VF损失相关,较长的轴长可能会在高度近视的NTG患者中加速进展.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 医疗成像医学成像
背景情况:
- 正常张力玻璃眼 (NTG) 是一种渐进的视神经病变,其特点是视野 (VF) 损失,尽管眼内压力正常.
- 微血管和结构变化是青光眼进展的关键指标,但它们在NTG中的纵向行为,特别是高近视,需要进一步调查.
研究的目的:
- 纵向评估正常张力玻璃眼 (NTG) 眼睛的结构,微血管和功能变化.
- 为了比较高近视和没有高近视的NTG眼睛的进展模式,使用光学连贯性断层扫描血管学 (OCTA) 和VF参数.
主要方法:
- 分析了61只NTG眼睛,其中25只被归类为高度近视 (轴长≥26毫米).
- 评估了OCTA参数的变化率 (辐射周毛细血管密度,偏血管密度,深偏血管密度,RNFL厚度,GCC厚度).
- 评估了OCTA参数变化,VF平均偏差 (MD) 损失和轴长 (AL) 之间的相关性.
主要成果:
- 尽管VF MD变化不显著,但在辐射周毛细血管VD,面膜膜膜膜,深面膜膜膜和RNFL厚度方面观察到显著的损失率.
- 这些OCTA参数变化在高度近视和非高度近视的NTG眼睛之间没有显著差异.
- 在近视和非近视NTG眼中,VF MD变化与对膜VD变化相关. 在高度近视的眼睛中,AL与RNFL稀释和VF损失负相关.
结论:
- 正常紧张型玻璃眼 glaucoma 眼睛可以表现出微血管和结构性恶化,即使视野稳定.
- 降低状血管密度与NTG中的VF进展相关,证实了结构功能关系.
- 在高度近视的NTG眼睛中,轴长度增加可能与加速的RNFL稀释和VF损失有关.
更多相关视频
08:55Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
3.1K
07:18Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
1.8K
相关概念视频
01:25Glaucoma: Overview
573
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
573
01:27Open Angle Glaucoma: Treatment
452
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
452
01:28Angle Closure Glaucoma: Treatment
500
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
500