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工程基酶活动,选择性和稳定性,以进行可扩展的关键中间体的简洁合成,使其成为贝尔祖提芬

Wai Ling Cheung-Lee1, Joshua N Kolev1, John A McIntosh1

  • 1Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.

Angewandte Chemie (International ed. in English)
|January 27, 2024
PubMed
概括

工程酶使得直接的,选择性的C-H键氧化成为贝尔祖提凡合成的可能. 这种生物催化方法取代了多步化学过程,为瘤药物制造提供了更绿色,更有效的途径.

关键词:
生物催化剂是一种生物催化剂.定向进化的指导进化酵素工程是什么意思 酵素工程氧化的方法是这是一种α-甲基酸盐依赖的二氧化酶.

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