MDMA增强了对社会反的积极情感反应
Anya K Bershad1, David T Hsu2, Harriet de Wit3
1Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA.
Journal of psychopharmacology (Oxford, England)
|January 27, 2024
概括
高剂量的3,4-甲基二氧化甲胺 (MDMA) 增强了对社会反的积极情绪反应. 这表明MDMA可能会改善社会联系,这需要在临床人群中进行进一步的研究.
科学领域:
- 心理药理学 心理药理学
- 社会神经科学是一种社会神经科学.
背景情况:
- 3,4-甲基二氧化甲胺 (MDMA) 是一种胺衍生物,作为PTSD的心理治疗辅助药物被探索.
- MDMA的潜在治疗效果可能源于其对社会观念产生积极偏见的能力.
- 以前的研究还没有研究MDMA对社会反的情感反应的影响.
研究的目的:
- 与安慰剂和甲基胺 (MA) 相比,研究MDMA对社会反的情感反应的影响.
- 为了确定MDMA是否影响对积极和消极社会线索的反应.
主要方法:
- 进行了一项双盲,安慰剂控制,交叉试验 (NCT03790618).
- 健康的成年志愿者 (N=36) 接受了两剂MDMA (0.75 mg/kg,1.5 mg/kg),安慰剂或MA (20 mg) 的剂量.
- 参与者完成了一个个性化的社交反任务,模拟约会应用程序界面.
主要成果:
- 高剂量的MDMA (1.5mg/kg) 显著增加了对社会反的积极情感反应.
- 较低的MDMA剂量或甲基胺对社会反的情感反应没有显著影响.
结论:
- 通过增强对社会反的积极情感反应,MDMA可能会促进社会联系.
- 需要进一步的研究来探索MDMA对一般社会反和临床人群的影响,特别是患有PTSD的人群.
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