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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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白物质的偏磁边缘和非边缘病变在多发性硬化症中具有共享的周周结膜梯度:一项7-T成像研究

Alessandro Miscioscia^1,2, Constantina A Treaba^1,3, Valeria T Barletta^1,3

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

Multiple sclerosis (Houndmills, Basingstoke, England)

|January 27, 2024

概括

在多发性硬化症 (MS) 中,偏磁边缘病变 (PRL) 和非边缘白质病变集中在心室的脑脊液 (CSF) 附近. 脊髓靠近影响两种损伤类型,并预测神经障碍.

科学领域:

神经成像是一种神经成像.
多发性硬化症的病理生理学
白质病变 - - 白质病变

背景情况:

偏磁边缘病变 (PRL) 与不复发的多发性硬化症 (MS) 进展有关.
脑脊液 (CSF) 溶解因子在PRL形成中的作用尚不清楚.

研究的目的:

调查PRL和非边缘白质 (WM) 病变相对于心室CSF的分布.
检查病变表型,皮质病变和神经障碍之间的关联.

主要方法:

使用7-特斯拉MRI来量化病变体积 (PRL,非边缘WM,白皮层,亚皮层/皮层内).
根据距离心室的距离,将WM细分为同心圆环,以分析病变分布.
包括61名多发性硬化患者,至少有一名PRL.

主要成果:

无论是PRL还是非边缘WM的病变体积在周心室区域都是最高的,并且随着距离心室的距离而减少.
在非边缘WM病变,PRL和白皮层病变 (LCL) 之间观察到一个CSF距离独立的关联.
周心室非边缘WM病变体积是神经障碍最强的预测因素.

结论:

在PRL和非边缘WM病变中,从心室到皮层的分布梯度相似.
脊髓附近的位置似乎影响了MS中两种围膜瘤类型的患病率.
了解这些分布模式可能会为MS进展机制提供洞察力.

关键词:

7-T 阶段 7-T 阶段在CSF的梯度上.偏磁边缘损伤偏磁边缘损伤慢性MS病变的病变皮层损伤 - 皮层损伤在燃烧的MSMS中.

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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...