在被诊断为过早卵巢衰竭的妇女中先前的癌症:一项基于全国人口的病例控制研究
Heidi Silvén1,2,3, Susanna M Savukoski1,2,3, Paula Pesonen4
1Department of Obstetrics and Gynecology, Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Oulu, Finland.
Acta obstetricia et gynecologica Scandinavica
|January 27, 2024
概括
与普通人群相比,早产卵巢缺陷 (POI) 的女性在癌症诊断前的患病率明显更高. 癌症治疗可能是POI的病因因素,强调了癌症幸存者早期干预的必要性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 过早卵巢衰竭 (POI) 影响40岁以下的女性,影响生育能力和长期健康.
- 之前的癌症诊断和POI的发展之间的关系需要进一步调查.
研究的目的:
- 为了确定POI的女性先前癌症诊断的患病率.
- 为了将这种患病率与一般人群中年龄相匹配的对照进行比较.
- 探索癌症,癌症治疗和POI之间的联系.
主要方法:
- 全国范围的病例控制研究使用芬兰注册数据 (1953-2018).
- 确定了5221名POI妇女 (在40岁之前被诊断出POI) 和20822名匹配的对照.
- 分析了先前癌症诊断的几率比率 (OR),按癌症类型,年龄和时间间隔分层.
主要成果:
- 21.9%的POI女性先前被诊断患有癌症,而对照组只有0.8% (OR 36.5).
- 在癌症诊断后2年内,POI的风险最高 (OR 103).
- 即使在10年后,POI风险的升高仍然存在 (OR 5.40).
结论:
- 患有POI的女性患有癌症的患病率是前癌症的27.5倍.
- 癌症治疗被认为是POI的潜在原因.
- 在癌症幸存者中早期识别POI风险对于及时诊断和管理至关重要.
相关概念视频
Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Disorders of the Female Reproductive System
363
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
363


