Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Ankle Joint

Ankle Joint

The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Short-term neurovascular and electrophysiological responses to combined visual and vibration stimulation in older adults with mild cognitive impairment.

Frontiers in aging neuroscience·2026

Same author

Differential temporal responses of heel strike and toe off during split-belt locomotor adaptation.

European journal of applied physiology·2026

Same author

Graded ankle instability induces early osteoarthritic changes in a rat model.

Osteoarthritis and cartilage open·2026

Same author

Habitual exercise prior to intracerebral hemorrhage primes brain environment against injury in a dose-dependent manner of the exercise.

Biomedical research (Tokyo, Japan)·2026

Same author

FOXO1-mediated cell cycle arrest enhances osteogenic differentiation of spheroid-cultured human periodontal ligament-derived multipotent mesenchymal stromal cells.

Regenerative therapy·2026

Same author

Cerebellar neuromodulation synchronized to ankle-assist cycling yields prolonged post-assist dorsiflexion.

Medical engineering & physics·2026

Search research articles

相关实验视频

Updated: Jul 4, 2025

Evaluating Postural Control and Lower-extremity Muscle Activation in Individuals with Chronic Ankle Instability

Evaluating Postural Control and Lower-extremity Muscle Activation in Individuals with Chronic Ankle Instability

Published on: September 18, 2020

慢性脚关节不稳定导致脚感觉运动功能障碍:一项受控实验室研究

Sora Kawabata^1,2, Kaichi Ozone^1,3, Yuki Minegishi^1,4

¹Department of Health and Social Services, Health and Social Services, Graduate School of Saitama Prefectural University, Saitama, Japan.

The American journal of sports medicine

|January 27, 2024

概括

脚不稳定导致机械受体退化和感官神经元敏感性降低,导致慢性脚不稳定 (CAI). 脚扭伤后的早期干预对于预防CAI发展至关重要.

关键词:

脚脚在脚上这些带和带.物理治疗疗法物理治疗

更多相关视频

A Mouse Model of Ankle-Subtalar Complex Joint Instability

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

Experimental Methods to Study Human Postural Control

Experimental Methods to Study Human Postural Control

Published on: September 11, 2019

相关实验视频

Last Updated: Jul 4, 2025

Evaluating Postural Control and Lower-extremity Muscle Activation in Individuals with Chronic Ankle Instability

Evaluating Postural Control and Lower-extremity Muscle Activation in Individuals with Chronic Ankle Instability

Published on: September 18, 2020

A Mouse Model of Ankle-Subtalar Complex Joint Instability

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

Experimental Methods to Study Human Postural Control

Experimental Methods to Study Human Postural Control

Published on: September 11, 2019

科学领域:

生物力学生物力学
神经科学是一个神经科学.
整形外科整形外科整形外科

背景情况:

慢性脚不稳定性 (CAI) 经常跟随脚扭伤,导致由于感觉运动功能障碍而导致的复发性损伤.
在最初的带损伤后,CAI病原体的确切机制仍然不完全理解.

研究的目的:

用动物模型研究机械受体退化和改变机械敏感性在CAI发展中的作用.
阐明脚不稳定性,机械受体完整性和感觉运动功能之间的关系.

主要方法:

脚关节不稳定性 (AJI) 在Wistar大鼠中通过切断关节带进行手术诱导.
关节的不稳定性,感觉运动功能 (梯子行走,平衡梁),机械受体形态 (S100,神经丝) 和PIEZO2表达被术后评估.
进行了前额状带 (ATFL) 机械受体和感觉神经元机械敏感性的组织学分析.

主要成果:

与对照组相比,诱导脚不稳定的老鼠显示感觉运动功能下降,脚不稳定性增加.
在AJI组中观察到ATFL机械受体数量的显著减少和感觉神经元中PIEZO2表达的减少.
机械受体的数量与感觉运动功能障碍的程度有负相关性.

结论:

开发的AJI模型复制了CAI的关键特征,包括机械受体退化和神经元机械敏感性降低.
这些发现表明,机械受体受损和机械感应受损是慢性脚不稳定性病变的关键因素.