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将TIGIT阻塞与IL-15刺激结合起来,是肺腺癌的有前途的免疫疗法策略

Baohong Luo1, Yu Sun1,2, Qinru Zhan1,2

  • 1Molecular Diagnosis and Gene Test Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Clinical and translational medicine
|January 27, 2024
PubMed
概括

在肺腺癌 (LUAD) 中,T细胞免疫球蛋白和免疫受体氨酸基抑制动机域 (TIGIT) 升高,损害CD8+T细胞功能. 将IL-15与TIGIT阻塞结合起来可以增强LUAD中的抗瘤免疫力.

关键词:
在IL-15中,IL-15是最常见的.这是一个紧张的紧张.免疫疗法 免疫疗法肺部腺癌的癌症

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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