改变药物的使用在消化不良:加厚剂对药物的生物可用性的影响 - - 一个系统的审查
Jayne Atkin1, Christopher Devaney2, Yuki Yoshimatsu3,4
1General Medicine, Kings College Hospital, Kings College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
European geriatric medicine
|January 27, 2024
概括
用于消化不良的加厚液体可能会改变口服药物的作用. 需要更多的研究来了解加厚剂对药物的生物可用性和患者结局的影响.
科学领域:
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
- 临床药房 临床药房
背景情况:
- 吞障碍 (吞困难) 在65岁以上的成年人中很常见,通常与多种慢性疾病和多种药物共发生.
- 加厚的液体是缺食症的常见补偿策略,但它们对药物疗效的潜在影响尚不清楚.
- 临床医生和药剂师对加厚液体对口服药物的药理动力学和治疗作用缺乏认识.
研究的目的:
- 系统地审查现有的关于液体加厚剂对口服药物的生物可用性影响的文献.
- 识别有关乱症管理策略与药物吸收之间的相互作用的知识差距.
主要方法:
- 使用MEDLINE和EMBASE数据库进行了系统的文献搜索.
- 搜索术语集中在食障碍,加厚的饮食,生物可用性,药物吸收和药理动力学上,但不包括动物研究和鼻胃养.
- 参与社区或医院环境中的成年人 (18岁以上) 的研究,不论性别或国家,都遵循了PRISMA指南.
主要成果:
- 该审查从570个结果的初始搜索中确定了18篇相关文章.
- 大多数研究评估了缩剂中的药物的体外溶解概况,体内调查较少.
- 研究结果表明,加厚剂通常会影响药物溶解率,但很少有研究评估了实际的生物可用性或临床结果.
结论:
- 有一个显著的缺乏理解关于如何改变液体粘度从加厚剂影响药物的治疗效果在老年人的消化不良和多药.
- 更大规模的研究是必要的,以调查各种加厚剂对更广泛的药物治疗的影响.
- 未来的研究应该考虑诸如加厚剂类型,粘度和浸泡时间等因素,以充分评估临床相关性.
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