通过红色和近红外激光照射改善人类精子的运动性:体外研究
Rasha Ahmed1, Omnia Hamdy2, Shaimaa Elattar3
1Urology Department, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt.
概括
使用红色 (650 nm) 和近红外 (980 nm) 波长的低水平激光疗法显著提高了人类精子的运动性. 这种光生物调节技术提高了精子的速度,而不影响DNA完整性,提供了潜在的生育益处.
科学领域:
- 生殖生物学 生殖生物学
- 生物医学工程 生物医学工程
- 照相医疗 (photomedicine) 是一种医学.
背景情况:
- 精子运动对于受精和怀孕的成功至关重要.
- 低水平激光疗法 (LLLT) 使用光生物调节来增强细胞功能.
- 线粒体细胞染色体c氧化酶吸收光线,使其成为LLLT改善精子运动的目标.
研究的目的:
- 研究650纳米红色激光,980纳米近红外激光 (NIR) 及其对人类精子运动性和DNA完整性的组合的影响.
- 为了确定最佳的激光参数,以提高精子功能在体外.
主要方法:
- 在实验室中进行了一项受控试验,使用了30个人类精液样本.
- 精液样本被暴露在650nm红色激光,980nmNIR激光和两者的组合中,持续时间不同.
- 使用WHO-2021手册指南评估精子运动性,使用精子染色质结构试验评估精子染色质完整性.
主要成果:
- 经过3分钟的650nm,980nm和组合激光照射,精子的总运动率分别增加了约70%,80%和100%.
- 在所有测试的激光类型和持续时间中,没有观察到对人类精子DNA碎片化或染色质完整性的明显影响.
结论:
- 低水平激光疗法,特别是980nm NIR和联合波长的激光疗法,在体外显著提高了人类精子的运动性.
- 在不损害DNA完整性的情况下,LLLT提供了一种有希望的,非侵入性的方法来改善精子功能.
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