相关实验视频

Updated: Jul 4, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

烯单氧酶促进了膀癌的发展,部分原因是通过调节PCNA来调节

Changyan Zhu¹, Xiao Fang², Xiangshen Liu¹

¹Department of Urology, Fuzong clinical medical college of Fujian Medical University, Fuzhou 350025, China.

Biochimica et biophysica acta. Molecular cell research

|January 27, 2024

概括

烯单氧酶 (SQLE) 在膀癌 (BC) 中被上调,促进瘤生长. 抑制SQLE可能为治疗膀癌提供了一个新的治疗策略.

科学领域:

在瘤学瘤学.
生物化学生化学
分子生物学分子生物学

背景情况:

膀癌 (BC) 是一种普遍存在的恶性瘤,其危险因素和机制尚未完全理解.
烯单氧酶 (SQLE) 与各种癌症有关,但其在BC中的作用尚不清楚.

研究的目的:

调查SQLE在膀癌发展和进展中的作用.
为了确定BC治疗的潜在治疗点.

主要方法:

对配对的BC和相邻的非癌性组织进行生物信息学分析.
试验室研究涉及SQLE在BC细胞中的敲击 (活力,亡,迁移,入侵测定).
RNA测序,基于质谱的互动组查,以及体内异种移植试验.

主要成果:

在BC组织中,SQLE表达显著上调.
SQLE的淘汰破坏了BC细胞的活力,诱导了细胞亡,并抑制了迁移和入侵.
SQLE 缺陷改变了参与增殖,迁移和亡的基因的表达.
增殖细胞核抗原 (PCNA) 被确定为一种SQLE相互作用的蛋白质.
在体内,SQLE抑制抑制了BC瘤的生长.

结论:

在促进膀癌的发展方面,SQLE起着至关重要的作用.
准SQLE代表了膀癌的潜在治疗策略.

关键词:

膀癌是一种癌症.增殖细胞核抗原 (PCNA) 是一种在RNA-seqqq.烯单氧化酶 (SQLE) 是一种烯单氧化酶.

更多相关视频

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

相关概念视频

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...