长期暴露于空气污染和中风风险的生态区域:REGARDS研究
Daniel W Riggs1, Kathy B Baumgartner2, Richard Baumgartner2
1Christina Lee Brown Envirome Institute, University of Louisville, Louisville, KY, United States; Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, United States.
长期暴露于空气污染,特别是PM10,会增加中风风险. 周围的生态或生态区域显著改变了这些关联,大平原的PM2.5风险更高.
科学领域:
- 环境流行病学环境流行病学
- 公共卫生 公共卫生
- 生态生态学 生态生态学
背景情况:
- 现有的队列研究将长期暴露于空气污染与增加中风风险联系起来.
- 生态因素在修改这些关联中的作用尚不清楚.
研究的目的:
- 评估不同生态区域如何改变空气污染与中风风险之间的关联.
- 评估不同生态区内特定空气污染物的中风发病率.
主要方法:
- 利用了来自26,792名参与者 (年龄在45岁以上) 的数据,研究了脑卒中地理和种族差异的原因 (REGARDS).
- 在人口普查区组级别的PM2.5,PM10,O3,NO2,SO2和CO的估计年均和三年平均值.
- 根据EPA生态区域分层使用的Cox比例危险模型,根据人口统计和风险因素进行调整.
主要成果:
- 一年PM10增加5.4μg/m3与整体中风风险比率增加7%相关 (HR=1.07).
- 在完全调整的模型中,没有发现PM2.5,O3,NO2,SO2或CO的显著关联.
- 在大平原生态区域 (HR=1.44) 中,PM2.5与中风的关联显著更强;PM10的关联在东部温带森林中最强 (HR=1.15).
结论:
- 长期暴露于空气污染和中风风险之间的关联因生态区域而异.
- 生态因素,包括环境资源的类型,质量和数量,影响空气污染对中风风险的影响.
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