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VEGF信号传递:在血管生成和其它方面发挥作用
Pallab Shaw1, Shailendra Kumar Dhar Dwivedi2, Resham Bhattacharya2
1Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Biochimica et biophysica acta. Reviews on cancer
|January 27, 2024
概括
血管内皮生长因子 (VEGF) 驱动血管生成并影响瘤微环境相互作用. 本综述详细介绍了VEGF的情况.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 血管新生是由血管内皮生长因子 (VEGF) 驱动的,对瘤生长和生存至关重要.
- VEGF在新血管化中的既定作用至关重要,但它对瘤微环境的更广泛影响不太了解.
研究的目的:
- 审查VEGF在瘤微环境中的血管生成之外的多方面的作用.
- 探索VEGF对细胞间通信的影响,包括细胞间和免疫细胞相互作用.
- 讨论VEGF在瘤新陈代谢,干性和上皮细胞-介质细胞过渡 (EMT) 的参与.
主要方法:
- 关于研究癌症中的VEGF信号的综合文献综述.
- 分析VEGF对细胞过程的影响,如增殖,迁移和细胞间交叉通话.
- 评估目前的抗VEGF疗法及其临床局限性.
主要成果:
- VEGF显著影响细胞周围细胞的行为,并调解瘤相关的巨细胞和癌细胞之间的相互作用,导致免疫抑制 (PD-L1) 和EMT (Nrf2).
- VEGF信号传递涉及器官内交叉通讯,瘤代谢,癌症干性和EMT.
- 目前的抗VEGF疗法在克服瘤耐药性和异质性方面存在局限性.
结论:
- VEGF是多种瘤过程的关键调节者,超出了其在血管生成中的作用.
- 了解VEGF对瘤微环境的全面影响对于开发更有效的癌症疗法至关重要.
- 针对VEGF及其下游途径提供了改善癌症治疗策略的潜力.
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