在脏疾病中的尿路生物标志物
Esra Canki1, Esther Kho2, Joost G J Hoenderop1
1Department of Medical BioSciences, Radboudumc, Nijmegen, The Netherlands.
Clinica chimica acta; international journal of clinical chemistry
|January 27, 2024
概括
早期发现慢性病 (CKD) 是至关重要的. 本综述强调了有希望的尿路生物标志物,如KIM-1,用于诊断和管理CKD,改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物发现发现
- 分析化学 分析化学
背景情况:
- 慢性病 (CKD) 是一个全球性的健康问题,早期检测方法不足.
- 尿路生物标志物为早期CKD诊断和管理提供了一个有希望的途径.
- 分析技术的进步提高了尿液分析对CKD评估的潜力.
研究的目的:
- 审查用于检测CKD的尿液分析的新技术.
- 确定用于诊断和管理CKD的关键尿路生物标志物.
- 评估生物标志物在监测CKD进展和结果中的有用性.
主要方法:
- 通过使用以下术语进行了系统的文献搜索:CKD,生物标志物和尿液.
- 该审查涵盖了53项研究,并评估了37种不同的尿路生物标志物.
- 生物标志物的价值被评估为CKD诊断,进展监测,死亡率预测和毒性评估.
主要成果:
- 损伤分子-1 (KIM-1) 显示出强大的诊断潜力,随着发生的CKD而增加.
- 迪克科夫-3 (DKK3) 水平与估计的淋巴细胞过率 (eGFR) 的下降相关.
- 随着功能恶化,尿素 (UMOD) 水平下降;然而,没有单一的生物标志物足够评估死亡率或毒性.
结论:
- 新兴的尿分析技术,包括智能所,为生物标志物检测提供了新的机会.
- 几种尿路生物标志物显示出对CKD诊断和管理的潜力.
- 需要进一步的研究来验证用于全面CKD评估的生物标志物,包括死亡率和毒性.
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