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微流体纳米粒子合成用于口服固体剂型:迈向临床过渡过程的一步

Lucia Morelli1, Evelyn Ochoa1, Lucia Salvioni1

  • 1University of Milano-Bicocca, Department of Biotechnology and Bioscience, Piazza della Scienza 2, 20126 Milano, Italy.

International journal of pharmaceutics
|January 27, 2024
PubMed
概括

这项研究开发了使用纳米粒子 (NP) 来增强药物输送的稳定口服固体剂型. 微流体学使得NP生产得以一致,为纳米药物的临床转化铺平了道路.

关键词:
应用程序 应用程序临床过渡的临床过渡.微流体学 微流体学多个单位的剂量形式.这是口头传递.聚合物纳米颗粒的材料.

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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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