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高脂肪饮食影响树突细胞和T细胞透,在小鼠的牙周炎

Annie Shrestha¹, Yi Zhu², Aiman Ali²

¹Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Dentistry, Mt. Sinai Hospital, Toronto, Toronto, Ontario, Canada.

Journal of endodontics

|January 27, 2024

概括

一种高脂肪饮食 (HFD) 增加了在没有顶牙周炎 (AP) 的小鼠中免疫细胞的透. 然而,与正常小鼠相比,患有AP的肥胖小鼠显示出更大的病变,但与正常小鼠相比,炎症细胞水平相似,这表明HFD会影响AP中的免疫路径.

科学领域:

免疫学免疫学免疫学
口腔病理学口腔病理学
代谢综合征研究代谢综合征研究

背景情况:

饮食诱导的代谢综合征是顶性牙周炎 (AP) 进展的潜在因素.
了解AP的免疫反应,特别是代谢综合征的免疫反应,对于有效治疗至关重要.

研究的目的:

为了研究树突细胞 (DCs) 和T辅助细胞 (Th) 在正常与肥胖小鼠中具有AP的作用.
为了评估高脂肪饮食 (HFD) 在AP的背景下如何影响炎症反应.

主要方法:

小鼠被食正常的 (NC) 或HFD12周,然后诱导AP.
微计算机断层扫描 (micro-CT),组织学和免疫光染色被用于分析周周病变和免疫细胞透 (DCs,Th17,Treg细胞).

主要成果:

与NC养的小鼠相比,HFD养的小鼠表现出更大的AP病变.
在NC小鼠中,AP诱导增加了免疫细胞透.
单独的HFD,没有AP,导致DC增加和Th17透.
在HFD-AP和NC-AP组之间没有观察到DC和Th17的显著差异.

结论:

单靠HFD就会增加周围免疫细胞的透.
尽管HFD-AP小鼠的病变较大,但炎症细胞透与NC-AP小鼠没有显著差异.
HFD在周周区域影响DC和Th17通路,但它们在代谢综合征的AP中的特定作用需要进一步研究.

关键词:

亚皮性牙周炎 (apical periodontitis) 是一种牙周炎.在T细胞,T细胞.树突细胞是一种树突细胞.高脂肪的高脂肪的高脂肪.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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