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相关概念视频

Hallucinogens and Psychedelics01:27

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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微剂量迷幻药物:来自受控研究的当前证据

Robin J Murphy1, Suresh Muthukumaraswamy1, Harriet de Wit2

  • 1School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Biological psychiatry. Cognitive neuroscience and neuroimaging
|January 27, 2024
PubMed
概括
此摘要是机器生成的。

像 lysergic acid diethylamide (LSD) 这样的迷幻药物的微剂量显示出潜在的心理治疗效应. 有控制的研究表明,低剂量的LSD是安全的,并在健康成年人中产生急性神经和行为变化.

关键词:
Lysergic 酸二甲基胺的使用微剂量是指微剂量.迷幻药物 迷幻药物是一种精神药物.

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科学领域:

  • 心理药理学 心理药理学
  • 神经科学是一个神经科学.
  • 临床心理学 临床心理学

背景情况:

  • 微剂量,即定期服用低剂量的迷幻药物的做法,已经引起了人们对潜在的治疗益处的关注.
  • 对微剂量,特别是对lysergic acid diethylamide (LSD) 的控制科学评估是有限的.
  • 本综述侧重于严格控制的研究,以评估LSD微剂量的影响.

研究的目的:

  • 审查和综合来自对lysergic acid diethylamide (LSD) 微剂量的急性和重复影响的受控研究的证据.
  • 评估LSD微剂量对健康成年人的安全性和生理,行为和主观影响.
  • 确定研究中的差距,并建议微剂量研究的未来方向.

主要方法:

  • 对14项符合严格实验控制标准的研究进行了系统审查.
  • 包括使用双盲,安慰剂控制的设计与研究人员提供的lysergic acid diethylamide (LSD) 的研究.
  • 对人口统计数据和依赖措施的分析,包括生理,行为和主观影响.

主要成果:

  • lysergic acid diethylamide (LSD) 的急性微剂量 (5-20μg) 剂量依赖地影响了血压,睡眠,神经连接,社会认知,情绪和感知.
  • 观察到的效应是在10-20微克的LSD,但不是在5微克.
  • 没有报告严重的不良反应;重复服用LSD剂量不会改变情绪或认知.

结论:

  • 低剂量的lysergic acid diethylamide (LSD) 似乎是安全的,并且在健康的成年人中引起急性神经和行为影响.
  • 需要进一步的研究来探索患者群体和其他迷幻化合物的这些效应.
  • 调查微剂量作为精神疾病潜在的药理疗法需要进一步研究.