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德罗斯菲拉新基因的起源和结构演变在德罗斯菲拉新基因的起源和结构演变

Junhui Peng¹, Li Zhao²

¹Laboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY, USA.

Nature communications

|January 27, 2024

概括

新基因 (de novo基因) 经常来自非基因DNA,为蛋白质进化提供了洞察力. 这项研究揭示了Drosophilinae中的许多新基因出生时是很好的折叠的,其中一些在早期精子发育中发挥作用.

科学领域:

进化生物学是进化的生物学.
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

基因创新对进化至关重要.
从非基因序列的新基因起源是新基因的重要来源.
研究年轻基因提供了对蛋白质结构和功能起源的洞察.

研究的目的:

研究基因特异性新基因的起源,进化和蛋白质结构.
分析D. melanogaster.中新基因的特征.
了解早期生殖细胞在新基因起源中的作用.

主要方法:

整个基因组的对齐.
计算结构建模计算结构建模
祖先序列重建的重建.
单细胞RNA测序的一个细胞.

主要成果:

在D. melanogaster中确定了555个新的基因候选者,这些基因来自Drosophilinae血统.
观察到与年龄相关的de novo基因的逐渐功能或适应性转变.
发现了最小的整体蛋白质结构变化,许多候选人从原始位置被很好地折叠.
在早期的精子生成阶段发现了年轻的de novo基因的丰富.

结论:

在Drosophilinae中De novo基因显示有限的结构进化,通常起源于一个很好的折叠状态.
早期的生殖细胞可能在丸中产生新基因的产生中发挥关键作用.
这项研究提供了对Drosophilinae中新基因进化和结构动态的全面了解.

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