相关实验视频

Updated: Jun 28, 2026

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
13:31

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

Published on: February 12, 2015

8.8K

用基图案移植的M13菌体作为一种工具,用于检测大脑组织中的粉样β寡合体

Ivone M Martins1,2,3,4, Alexandre Lima5,6,7, Wim de Graaff7

  • 1CEB- Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal. ivone.martins@ceb.uminho.pt.

Communications biology
|January 27, 2024
PubMed
概括

显示粉样β (Aβ) 的合成M13菌体可以在阿尔茨海默病 (AD) 脑组织中检测早期的Aβ-寡合体. 这提供了一个新的,低成本的工具来识别这些关键的AD生物标志物.

更多相关视频

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease09:33

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Published on: December 26, 2016

8.0K
A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis06:17

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

11.9K

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...