淋巴细胞与甲状腺功能低下症在阻塞性睡眠呼吸暂停中的关联
Xiaoyan Fang1, Le Wang1, Chong Xu1
1Department of Respiratory and Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China.
BMC pulmonary medicine
|January 27, 2024
概括
较高的淋巴细胞计数与阻塞性睡眠呼吸暂停 (OSA) 患者的甲状腺功能低下风险增加有关. 淋巴细胞水平可以预测OSA患者的甲状腺功能低下症,有助于诊断.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 免疫学 免疫学 免疫学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍的睡眠障碍.
- 在OSA和甲状腺功能低下之间存在显著的关联.
- 淋巴细胞与OSA患者的甲状腺功能低下症发展有关.
研究的目的:
- 研究OSA患者的淋巴细胞计数和甲状腺功能低下症之间的关系.
- 为了确定淋巴细胞是否在OSA中预测甲状腺功能低下.
主要方法:
- 920名OSA患者接受了睡眠监测和甲状腺功能测试.
- 后勤回归确定了甲状腺功能低下症的预测因素.
- 接收器操作特征 (ROC) 分析确定了淋巴细胞计数切断值.
主要成果:
- 在920名OSA患者中,甲状腺功能低下的发病率为4.46%.
- 在甲状腺功能低下的OSA患者中观察到较高的淋巴细胞计数 (p<0.05).
- 淋巴细胞计数,ESS和性别独立预测甲状腺功能低下症;切断值为2.5 (×10*9/L) 表示风险增加.
结论:
- 在OSA中甲状腺功能低下的患病率与淋巴细胞计数相关.
- 淋巴细胞计数作为OSA中甲状腺功能低下的独立预测剂.
- 淋巴细胞计数证明了对并发性OSA和甲状腺功能低下症的诊断价值.
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