共同参与肉病:系统性审查和流行率,临床模式和结果的元分析
Terence Yeung1, Adrian Grebowicz1, Tatiana Nevskaya1
1Division of Rheumatology, Department of Medicine, Schulich School of Medicine, University of Western Ontario, London, ON, Canada.
类发病的关节参与影响了12%的患者,类关节炎 (SA) 发生在19%的患者中. 急性SA通常会影响下肢关节,并且经常与红血瘤结节有关.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 系统性自身免疫性疾病
背景情况:
- Sarcoidosis 是一种多系统性炎症性疾病,病因不明.
- 关节干扰 (JI) 是一种已知的癌症的临床表现,但其患病率和特征需要进一步阐明.
研究的目的:
- 系统地审查和综合有关 Sarcoidosis 的联合参与的流行率,模式,治疗和结果的数据.
- 描述状关节炎 (SA) 和关节痛的流行病学和临床特征.
主要方法:
- 在MEDLINE,EMBASE和Cochrane图书馆进行了系统的文献搜索,直到2022年7月.
- 聚合流行率估计 (PPE) 使用二项分布和随机效应模型进行计算.
- 使用元回归分析来调查异质性的来源.
主要成果:
- Sarcoidosis 的 JI 的总体患病率为 12%.
- 麻性关节炎 (SA) 的PPE为19%,关节痛为32%.
- 急性SA,主要影响下肢大关节,是常见的 (79%),经常与红血结节 (62%). 慢性SA通常涉及多关节和上肢关节.
结论:
- Sarcoid 关节炎发生在 Sarcoidosis 的早期,显著的患病率为 19%.
- 最常见的表现是下肢大关节的急性橄或多关节炎.
- 了解这些模式有助于诊断和管理与 Sarcoidosis 相关的关节表现.
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