动物天生的免疫的主要组成部分的演变
Rafael Cardoso Maciel Costa Silva1, Fábio Mendonça Gomes2
1Laboratory of Immunoreceptors and Signaling, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. rcmcs@biof.ufrj.br.
Journal of molecular evolution
|January 28, 2024
概括
所有动物都有共同的先天免疫机制. 本综述详细介绍了保存的动物免疫受体,信号通路和转录因子,这些因子参与识别病原体相关分子模式 (PAMPs) 和危险相关分子模式 (DAMPs).
科学领域:
- 免疫学 免疫学 免疫学
- 比较生物学的比较生物学
背景情况:
- 天生的免疫是动物王国中存在的一个基本的防御系统.
- 了解保存机制是解读各种免疫策略的关键.
研究的目的:
- 审查动物天生的免疫中保存的识别和响应机制.
- 突出关键的分子参与者和监管过程.
主要方法:
- 文献综述,重点关注先天免疫的保存成分.
- 对受体,信号蛋白和转录因子的分析.
- 检查炎症媒介和反应性氧物种 (ROS) 调节的研究.
主要成果:
- 确定了病原体相关分子模式 (PAMPs) 和危险相关分子模式 (DAMPs) 的保存受体.
- 详细的下游信号通路和控制免疫激活的转录因子.
- 突出了保存的炎症媒介和反应性氧物种 (ROS) 在免疫反应中的作用,包括血氧酶 (HOs).
结论:
- 动物的先天免疫依赖于保存的分子机械来检测病原体和危险.
- 这些保存的元素调节炎症反应,并由诸如ROS等因素调节.
相关概念视频
Introduction to Innate and Adaptive Immunity
4.0K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
4.0K
What is the Immune System?
111.3K
Overview
111.3K
Introduction to Lymphatic and Immune System
2.7K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
2.7K
Cells of the Adaptive Immune Response
988
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
988
Cells of the Innate Immune Response
1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K
Special Features of Adaptive Immunity
821
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
821


