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低甲状腺素血症和早产婴儿的体重速度
Meira Zibitt1, Brittany Ange2,3, Zanna Wynter1
1Department of Pediatrics, Augusta University, Augusta, GA, USA.
Journal of pediatric endocrinology & metabolism : JPEM
|January 28, 2024
概括
在早产婴儿的低自由甲状腺素 (FT4) 与缓慢生长有关. 这项研究定义了FT4和TSH水平,发现FT4,而不是TSH或治疗,会影响非常早产新生儿的生长速度.
科学领域:
- 新生儿内分泌学 新生儿内分泌学
- 儿科生长与发展 儿科生长与发展
背景情况:
- 过早的甲状腺低血压 (HOP) 是由低的自由甲状腺素 (FT4) 和正常/低的甲状腺刺激激素 (TSH) 定义的.
- 了解FT4和TSH动态对于非常早产婴儿的生长和发育至关重要.
研究的目的:
- 为了确定非常早产婴儿 (<32周月经后年龄,PMA) 的FT4和TSH参考值.
- 为了研究HOP,甲治疗和28天和36周PMA的生长速度之间的关联.
主要方法:
- 对589名早产新生儿 (<32周PMA) 进行了回顾性分析,对HOP进行了查.
- 在出生后4-14天之间测量FT4和TSH水平.
- 增长速度的计算和多变量回归分析,包括PMA,性别和种族.
主要成果:
- 婴儿出生时的月经后年龄与FT4和TSH水平相反相关.
- 自由甲状腺素 (FT4) 和妊娠年龄与28天和36周PMA的生长速度显著相关.
- 甲状腺刺激激素 (TSH) 水平和levothyroxine治疗没有显示出与生长速度的显著关联.
结论:
- 这项研究为非常早产婴儿的FT4和TSH参考范围提供了大量数据集.
- 过早产生的甲状腺血可能是导致这一脆弱人群产后生长受损的重要因素.
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