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Updated: Jul 4, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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对HDAC4-MEF2A-DNA复合体的结构见解及其对远程转录调节的影响

Shuyan Dai1,2, Liang Guo3, Raja Dey4

  • 1Department of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Nucleic acids research
|January 28, 2024
PubMed
概括

类IIa 像HDAC4这样的基因脱甲基酶 (HDAC) 通过与MEF2转录因子相互作用来调节基因表达. 这项研究揭示了HDAC4-MEF2A-DNA复合体的结构基础,表明HDAC4二分化是基因抑制的关键.

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