针对外围动脉疾病的药物排泄支架中的不同药物:系统评估和贝叶斯元分析
Keqin Chen1, Lei Xu2, Xiehong Liu3
1Department of Vascular Surgery, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University (The First Hospital of Changsha), 311 Yingpan Road, Changsha City, 410005, Hunan Province, China. 153417179@qq.com.
Journal of thrombosis and thrombolysis
|January 28, 2024
概括
药物排泄支架 (DES) 改善了周围动脉疾病 (PAD) 的结果. 常胺排泄支架 (DES-Evero) 显示出最好的通透性,但常胺排泄支架 (DES-Siro) 具有更好的重血管化率.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 生物材料科学 生物材料科学
背景情况:
- 周围动脉疾病 (PAD) 需要有效的治疗选择.
- 药物排泄支架 (DES) 是症状PAD的主要治疗方法.
- 由于DES疗效的变化,需要进行比较结果分析.
研究的目的:
- 为了比较外围动脉封闭性疾病 (PAOD) 的各种DES的长期,现实世界的结果.
- 评估不同类型的DES和药物度对初级通透性 (PP) 和目标损伤再血管化 (TLR) 的疗效.
主要方法:
- 在Cochrane Library,Embase和PubMed数据库中进行系统的文献搜索,直到2023年3月25日.
- 包括32项涉及5467名患者的研究.
- 主要终点:6个月初级通透性 (PP) 和目标病变再血管化 (TLR).
主要成果:
- 与裸金属支架 (BMS) 相比,DES-Evero 1 ug/mm2显示出优越的PP.
- 一些DES类型,包括DES-Siro和DES-PTX,比BMS显示出明显更好的PP.
- DES-Siro 0.9 ug/mm2获得了最佳的TLR,而DES-Evero 1 ug/mm2则获得了最高的再干预率.
结论:
- 在PAD治疗中,DES提供了比BMS更好的PP和TLR.
- 在PP中,DES-Evero 1 ug/mm2优于PP,但具有更高的再干预风险.
- 排泄西罗利斯 (sirolimus) 的支架和排泄埃弗罗利斯 (everolimus) 的支架通常表现优于排泄帕克利塔塞尔 (paclitaxel) 的支架.
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