低剂量的sugammadex可以在马中逆转中度罗库诱导的神经肌肉阻塞
Manuel Martin-Flores1, Daniel M Sakai2, Joaquin Araos1
1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Equine veterinary journal
|January 28, 2024
概括
低剂量的苏加马德克斯显著减少了马匹因罗库诱导的神经肌肉阻塞 (NMB) 的恢复时间,将其从21分钟缩短到4分钟. 这项研究证明了sugammadex.
科学领域:
- 兽医麻醉学 兽医麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在全身麻醉期间的神经肌肉阻塞 (NMB) 存在恢复期间残留NMB的风险.
- 传统的逆转药物,如尼奥斯蒂格明/阿特罗宾,具有显著的副作用.
- 苏加马德克斯可以有效地逆转罗库诱导的NMB,而无需这些并发症,尽管推剂量可能昂贵.
研究的目的:
- 为了比较使用低剂量的sugammadex与马匹自发恢复的rokuronium诱导NMB的恢复时间.
主要方法:
- 不随机的体内研究涉及14匹成年马.
- 马匹接受了罗库 (0.3毫克/公斤IV) 治疗NMB.
- 神经肌肉功能通过加速肌图学四人列车 (TOF) 比率进行评估.
- 5匹马的自发恢复; 9匹马的苏加马德克斯 (总剂量200毫克).
主要成果:
- 苏加马德克斯的剂量平均为0.46 mg/kg.
- 恢复时间到TOF比率1.0显著减少:4分钟 (sugammadex) 和21分钟 (自发).
- 与自发恢复 (58分钟) 相比,总NMB持续时间也较短的sugammadex (36分钟).
- 在sugammadex给药后30分钟内没有观察到复发的情况.
结论:
- 一个低剂量的苏加马 (大约. 0.5毫克/公斤) 显著加快了马匹中罗库诱导的NMB的恢复.
- 这种低剂量的sugammadex疗法似乎是安全的,没有观察到复发.
- 需要使用更大的样本大小进行进一步的研究.
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