植物衍生化合物作为针对COVID-19的新药开发的潜在途径
Lingxiu Liu1,2, Maxim Kapralov3, Mark Ashton1,2
1Faculty of Medical Sciences, School of Pharmacy, Newcastle University, Newcastle-Upon-Tyne, UK.
Phytotherapy research : PTR
|January 28, 2024
概括
药用植物显示出开发新的COVID-19治疗方法的希望. 研究正在探索植物提取物和化合物对抗SARS-CoV-2的抗病毒活性,并对动物模型和人类进行研究.
科学领域:
- 药理学和民族植物学
- 传染病和病毒学 传染病和病毒学
背景情况:
- 由SARS-CoV-2引起的COVID-19具有从轻度到重度的一系列症状,并有可能导致严重的并发症.
- 目前的治疗方法,如雷梅西维尔,甲松和单克隆抗体已经改善了结果,但迫切需要新的治疗方法仍然存在.
- 药用植物是药物的历史来源,并具有广泛的抗病毒特性,使他们成为COVID-19治疗开发的潜在候选人.
研究的目的:
- 审查药用植物及其生物活性化合物对SARS-CoV-2 (COVID-19) 的治疗潜力.
- 探索植物衍生抗SARS-CoV-2活性的体外,动物模型和人类研究证据.
主要方法:
- 对评估药用植物提取物和隔离化合物的抗SARS-CoV-2活性研究的文献综述.
- 对这些植物衍生物剂的细胞和分子相互作用的分析.
- 专注于体外试验,动物模型和人类临床研究的证据.
主要成果:
- 在体外研究中,各种药用植物提取物已经证明了抗SARS-CoV-2活性.
- 从植物中分离出来的特定生物活性化合物显示出潜在的治疗作用.
- 目前正在研究动物模型和初步人类研究的证据.
结论:
- 药用植物代表了开发新抗病毒治疗SARS-CoV-2的有希望的资源.
- 对植物衍生化合物及其临床应用的进一步研究是有必要的,以对抗COVID-19大流行.
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