胸膜增生和血清水平在格雷夫病中的关联
Jing Zeng1,2, Lan Li1,3, Dong Wei4
1Department of Endocrinology and Metabolism, The Second People's Hospital of Chengdu, No.10 Qingyunan Street, Jinjiang District, Chengdu, 610017, China.
BMC endocrine disorders
|January 28, 2024
概括
患有胸膜增生症的格雷夫斯病患者表现出较高的血清水平. 这表明,胸膜增生可能会在格雷夫斯病中恶化骨动员,与TRAb和女性性别一起.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 免疫学 免疫学 免疫学
背景情况:
- 格雷夫斯病与增加的骨吸收和高血症有关.
- 胸膜增生发生在一些格雷夫斯病患者身上,据报道与高热血症和骨质疏松症有关.
- 在格雷夫斯病中,胸膜增生和血清水平之间的关系需要进一步调查.
研究的目的:
- 为了检查患有胸膜增生症的格雷夫斯病患者是否有血清水平升高.
- 探索胸膜增生和格雷夫斯病中严重的骨动员之间的关联.
主要方法:
- 招募了96名新诊断的未经治疗的格雷夫斯病患者.
- 患者根据通过成像检测到的胸膜激增的存在或不存在将患者分为几组.
- 测量血清,甲状腺激素,TRAb和其他生化标志物;进行CT扫描.
主要成果:
- 胸腺增生症患者年轻,血清水平显著提高.
- 胸膜增生,TRAb水平和女性性别独立地与血清的升高有关.
- 这些因素共同解释了血清水平变化的31.7%.
结论:
- 患有胸膜增生症的格雷夫斯病患者表现出较高的血清水平.
- 胸膜增生与格雷夫斯病的血清含量增加相关,这表明它在骨动员中起作用.
- 在这个患者群体中,TRAb和女性性别也与血清的升高相关.
相关概念视频
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:21Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K
00:51Synthesis and Functions of Calcitonin
1.9K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.9K
00:59The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
01:20Synthesis and Regulation of Thyroid Hormones
4.6K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.6K