缺少ASGR1将脂质转移到脂肪组织,但在肥胖期间会导致肝损伤
Monika Svecla1, Lorenzo Da Dalt1, Annalisa Moregola1
1Department of Pharmacological and Biomolecular Science "Rodolfo Paoletti", Università degli Studi di Milano, Milan, Italy.
Cardiovascular diabetology
|January 28, 2024
概括
亚洲糖蛋白受体1 (ASGR1) 缺乏在小鼠中恶化肝炎和脂肪积累在内脏脂肪组织,尽管在肥胖期间改善了血脂水平.
科学领域:
- 代谢性疾病研究研究.
- 肥胖和代谢综合征研究的研究.
- 肝病学和心血管研究.
背景情况:
- 肝细胞上的亚洲糖蛋白受体1 (ASGR1) 清除循环中的糖蛋白和脂蛋白.
- 人类ASGR1功能丧失变体与有利的代谢概况和心血管疾病减少相关.
- ASGR1在代谢综合征和肥胖病原体中的作用尚不清楚.
研究的目的:
- 研究ASGR1在代谢综合征的发展中的作用.
- 为了阐明ASGR1对肥胖的贡献.
主要方法:
- 缺少ASGR1 (ASGR1-/-) 的小鼠在20周内被食高脂肪饮食 (45%Kcal来自脂肪).
- 评估了系统代谢概况.
- 分析了肝脏和内脏脂肪组织的代谢,结构和免疫细胞变化.
主要成果:
- ASGR1-/-小鼠表现出过度缩的脂肪组织,内脏脂肪组织 (VAT) 脂肪积累增加 (41%),脂质代谢发生变化.
- 在ASGR1-/-小鼠中,循环胆固醇水平下降,葡萄糖和胰岛素反应相似.
- 与野生型小鼠相比,ASGR1-/-小鼠表现出肝炎升高和线粒体功能降低,尽管与野生型小鼠相比,肝脏脂质积累类似.
结论:
- 在肥胖期间,ASGR1缺乏会影响能量恒温.
- 缺少ASGR1导致血脂水平改善,但增加了增值税脂积累和肝损伤.
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