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在接受基于社区的型肝炎病毒治疗的人群中,乙型肝炎病毒易感性的高患病率

Catherine Campusano^1,2, Rachel Kanner³, Claire McDonell⁴

¹Department of Medicine, School of Medicine, University of California, San Francisco, CA, USA. catherine.campusano@northwestern.edu.

Harm reduction journal

|January 28, 2024

概括

许多感染C型肝炎病毒 (HCV) 的人仍然容易感染乙型肝炎病毒 (HBV),这凸显了HBV疫苗接种中的关键差距. 建议将HBV疫苗接种与基于社区的HCV治疗相结合.

科学领域:

肝病学肝病学是一种肝病学.
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

与乙型肝炎病毒 (HBV) 和乙型肝炎病毒 (HCV) 的同时感染是常见的,这是由于共享的传播途径.
建议所有感染HCV且对HBV敏感的个体接种HBV疫苗.
识别HBV疫苗接种方面的差距对于这种高风险人群至关重要.

研究的目的:

在接受社区 HCV 治疗的个体中确定 HBV 易感性模式.
为了确定这一群体内HBV疫苗接种覆盖率的潜在差距.

主要方法:

在两个美国城市社区的HCV治疗计划中进行了一项横截面研究.
参与者是通过街头外展招募的,目标是那些经历无家可归和吸毒的人.
排除标准包括反应性HBsAg;通过调查获得队列特征;进行描述性分析.

主要成果:

在150名没有慢性HBV的参与者中,31%的人对HBV没有免疫力.
在目前注射药物使用者 (IDU) 中,年龄较小的年龄组 (年龄为24-40岁的31%,年龄为41-57岁的47%) 的敏感性更高.
较老的参与者 (58-74岁) 由于先前的接触,显示出更高的HBV免疫力 (84%).

结论:

在接受基于社区的HCV治疗的个人中存在HBV易感性的显著流行.
患有HCV的年轻人,特别是那些报告当前IDU的人,在HBV疫苗接种中表现出明显的差距.
建议将HBV疫苗接种与HCV查和治疗计划同时进行本地化,以弥补这一差距.

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