优化基于网络的自然语言处理方法,以揭示COVID-19中疾病并发症
Emre Taylan Duman1,2, Gizem Tuna3, Enes Ak4
1Department of Bioengineering, Gebze Technical University, Kocaeli, Turkey. emretaylanduman@gmail.com.
Scientific reports
|January 28, 2024
概括
这项研究使用深度学习来通过分析miRNA相互作用来发现新的COVID-19并发症. 这些发现有助于预测疾病联系,并为未来的流行病准备提供信息.
科学领域:
- 计算生物学是一种计算生物学.
- 网络医学 网络医学
- 病毒学 病毒学
背景情况:
- 由于COVID-19的流行,人们需要了解并发症,以获得更好的医疗保健.
- 识别并发症的传统方法缺乏机械的洞察力.
- 预测并发症对于优先考虑护理和开发疗法至关重要.
研究的目的:
- 使用深度学习方法发现未知的COVID-19并发症.
- 通过miRNA调节相互作用获得有关疾病联系的机制性见解.
- 整合多种疾病的数据,以提高共发病性检测.
主要方法:
- 利用基于文字嵌入技术的修改深度学习算法 (mpDisNet).
- 从SARS-CoV-2感染细胞和它们的目标转录因子中整合的miRNA表达特征.
- 应用网络医学原则,通过miRNA介导的调节相互作用连接疾病.
主要成果:
- 该算法成功预测了大多数已知的COVID-19并发症.
- 确定了与COVID-19相关的几种潜在的新型并发症.
- 证明了通过miRNA调节通路连接疾病的发现能力.
结论:
- 深度学习提供了一种强大的方法来发现机理学信息的并发症.
- 发现的新型并发症需要进一步调查,以提高认识和预防.
- 这种方法推进了网络医学,并有助于为未来的疫情做好准备.
相关概念视频
Classification of Illness
7.5K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.5K
Single Nucleotide Polymorphisms-SNPs
15.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.1K
Principles of Disease Surveillance
96
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
96
Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
COPD: Pathogenesis and Clinical Features
274
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
274
Genomics
36.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.3K


